Mismatch Repair (MMR) Responses to DNA Lesions

Program

Session I, Fri. evening Sept. 9 (Portland): Biochemical Mechanisms
R. Michael Liskay (Chair) OHSU: MMR mutation avoidance functions in yeast and mammals..

John Hays, OSU: Activities of MMR recognition complexes at base-mismatches and mismatched UV photoproducts.

Jim Drummond, Indiana U: Human MMR responses to oxidized purines, O6-methylguanine and other lesions in vitro.

TBA: Selected poster talk.

Discussion

Session II, Sat. morning Sept. 10 (Corvallis): Cellular Surveillance and Signaling.
Niels de Wind (Chair) LUMC, Leiden: MMR involvement in UV-induced S-phase arrest and mutagenesis.

Margherita Bignami, ISS, Rome: MMR and oxidative damage.

Alan Clarke, U. of Cardiff, UK: MMR-dependen t apoptosis in the mouse small intestine in response to alkylating agents.

Rajaskeran Baskaran, U. of Pittsburgh, MMR-dependen t cell -cycle- checkpoin t activation in response to cisplatin and alkylating agents

David Boothman, U. Texas SW Medical Center: MMR-mediated G2 arrest responses and apoptosis following MNNG exposure

Discussion

Session III, Sat. evening, Sept. 10 (Corvallis): Implications for Mutagenesis and Carcinogenesis.

Peter Karran (Chair), Cancer Research, UK: Drug resistance, MMR defects, and therapy-related acute myeloid leukemia in organ-transplant patients.

Andrew Buermeyer, OSU: MMR suppression of hetercyclic-amine-induced mutagenesis and carcinogenesis.

Mitchell Turker, OHSU: Unexpected MMR roles in suppression of mutation induced by UV irradiation, oxidative DNA damage, and IR.

Winfried Edelmann, Albert Einstein Med: Cancer predisposition and responses to DNA damage in MMR-deficient mice.

Rick Boland, Baylor Med: Implications of defective MMR for colorectal cancer.

Discussion